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Cell Cycle/Ubiquitin-dependent Proteolysis

  1. Tsunematsu T, Arakaki R, Kawai H, Ruppert J, Yamada A, Tsuneyama K, Ishimaru N, Earnshaw WC, Pagano M, Kudo Y*. APC/C-Cdh1 is required for the termination of CPC activity upon mitotic exit. J Cell Sci 133(18):jcs251314, 2020.

  2. Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, Florens L, Washburn MP, Stadtfeld M, Pinton P, Pagano M. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol 19(4):341-351, 2017.

  3. Tsunematsu T, Takihara Y, Ishimaru N, Pagano M, Takata T, Kudo Y*. Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. Nat Commun 4:1885, 2013. 

  4. Shimizu N, Nakajima NI, Tsunematsu T, Ogawa I, Kawai H, Hirayama R, Fujimori A, Okayasu R, Ishimaru N, Takata T, Kudo Y*. Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells. J Biol Chem 288(24):17238-17252, 2013.

  5. D'Angiolella V, Donate V, Forrester FM, Jeong YT, Pellacani C, Kudo Y, Saraf A, Florens L, Washburn MP, Pagano M. Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell 149(5):1023-1034, 2012.

  6. Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizuka Y, Nakagama H, Poon RYC, Yamashita K. SCFßTrcp mediates stress-activated MAPK-induced Cdc25Bdegradation. J Cell Sci 124(Pt 16):2816-2825, 2011.

  7. Kudo Y*, Kitajima S, Ogawa I, Kitagawa M, Miyauchi M, Takata T. Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation. Mol Cancer Ther 4(3): 471-476, 2005.

  8. Kitajima S, Kudo Y*, Ogawa I, Bashir T, Kitagawa M, Miyauchi M, Pagano M, Takata T. Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Am J Pathol 165(6):2147-2155, 2004.

  9. Kudo Y, Guardavaccaro D, Santamaria PG, Nasu R, Latres E, Bronson R, Richardson A, Yamasaki Y, Pagano M. Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis. Mol Cell Biol 24(18):8184-8194, 2004.

  10. Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin F, Jackson P, Yamasaki L, Pagano M. Control of meiotic and mitotic progression by the F-box protein β-Trcp1 in vivo. Dev Cell 4(6):799-812, 2003. 

  11. Kudo Y, Kitajima S, Sato S, Miyauchi M, Ogawa I, Takata T. High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas. Cancer Res 61(19):7044-7047, 2001.

  12. Kudo Y*, Takata T, Yasui W, Ogawa I, Miyauchi M, Takekoshi T, Tahara E, Nikai H. Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is an indicator of malignant behavior in oral squamous cell carcinoma. Cancer 83(12):2447-2455, 1998. 

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Cancer invasion & metastasis

  1. Utaijaratrasmi P, Vaeteewoottacharn K, Tsunematsu T, Jamjantra P, Wongkham S, Pairojkul C, Khuntikeo N, Ishimaru N, Thuwajit P, Thuwajit C, Kudo Y*. The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells.​ Mol Cancer 17(1):10, 2018. 

  2. Kudo Y*, Iizuka S, Yoshida M, Tsunematsu T, Subarnbhesaj A, Siriwardena SB, Tahara H, Ogawa I, Takata T. Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis. J Biol Chem 287(46):38716-38728, 2012. 

  3. Hatano H, Kudo Y*, Ogawa I, Tsunematsu T, Kikuchi A, Abiko Y, Takata T. IFN-induced transmembrane protein 1 promotes the invasion at the early stage of head and neck cancer progression. Clin Cancer Res 14(19):6097-6105, 2008.

  4. Siriwardena BS, Kudo Y*, Ogawa I, Kitagawa M, Kitajima S, Hatano H, Tilakaratne WM, Miyauchi M, Takata T. Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. Br J Cancer 95(10):1396-1403, 2006. 

  5. Kudo Y*, Ogawa I, Kitajima S, Kitagawa M, Kawai H, Gaffney PM, Miyauchi M, Takata T. Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Cancer Res 66(14):6928-6935, 2006.

  6. Kudo Y*, Kitajima S, Ogawa I, Hiraoka M, Salgolzaei S, Keikhaee MR, Sato S, Miyauchi M, Takata T. Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous β-catenin. Clin Cancer Res 10(16):5455-5463, 2004.

  7. Kudo Y*, Takata T, Ogawa I, Sato S, Kaneda T, Takekoshi T, Zhao M, Miyauchi M, Nikai H. p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. Clin Cancer Res 6(3):916-923, 2000.

 

Others

  1. Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Takata T, Shimamoto A, Ochiya T, Tahara H. miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol 193(2):409-424, 2011.

  2. Iizuka S, Kudo Y*, Yoshida M, Tsunematsu T, Yoshiko Y, Uchida T, Ogawa I, Miyauchi M, Takata T. Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta 1 and CD63. Mol Cell Biol 31(4):783-792, 2011.

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